Operate the KF titrator using suitable operating procedure. A commercially available, stabilized solution of Karl Fischer type reagent may be used. Commercially available reagents containing solvents or bases other than pyridine or alcohols other than methanol may be used also.
The diluted Reagent called for in some monographs should be diluted as directed by the individual testing procedure. Either methanol or other suitable solvent, such as ethylene glycol monomethyl ether, may be used as the diluent.
The same solution shall be standardized. Standardization of KF Reagent by Water : Unless otherwise specified, transfer 35 to 40 mL of methanol or other suitable solvent to the titration vessel.
Neutralise the solvent with KF reagent. Weigh accurately between 25 to 250mg of water, transfer it into the titration vessel. Titer the content with Karl Fischer reagent to end point to the electrometric or visual endpoint. Perform the above titration in duplicate. Calculate the Factor using the formula
Neutralise, ethylene glycol monomethyl ether, pyridine, alcohols
The diluted Reagent called for in some monographs should be diluted as directed by the individual testing procedure. Either methanol or other suitable solvent, such as ethylene glycol monomethyl ether, may be used as the diluent.
The same solution shall be standardized. Standardization of KF Reagent by Water : Unless otherwise specified, transfer 35 to 40 mL of methanol or other suitable solvent to the titration vessel.
Neutralise the solvent with KF reagent. Weigh accurately between 25 to 250mg of water, transfer it into the titration vessel. Titer the content with Karl Fischer reagent to end point to the electrometric or visual endpoint. Perform the above titration in duplicate. Calculate the Factor using the formula
Neutralise, ethylene glycol monomethyl ether, pyridine, alcohols
Comments
Post a Comment