Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM. Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM . Chlorpheniramine displaces of pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM.
Chlorpheniramine Maleate Pellets, Pharmaceuticals, Maufacture, Chlorpheniramine Maleate Pellets 8% w/w
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